Transcript
0:10 Welcome everyone. Thank you so much for joining us today for this webinar webinar on the future of translational research. it's my pleasure to be joined today by doctors Dean Felchshire and Joanna Lillian. Before we get started, I just wanted to walk through a few housekeeping items. so first you should see in the in the interface that you're looking at there's a little Q&A button on the left hand side. If you have any questions at any time during the session about anything feel free to put those in the Q&A. We'll answer as many of them as we can at the end of the session. I have some colleagues who are also online. They may be able to answer some of those questions as they come in and then again at the end we'll get to as many as we can. We probably won't be able to get to every question but we'll do it the best that we can. Additionally, if you have to leave or you have a colleague you really love the webinar and you have a colleague who would enjoy it, we will be sending a recording of the session out in about a week or two weeks. So, at that point, you should be able to share that recording with anybody who wanted to or if you have to jump off in 30 or 40 minutes and you miss the very end, you can jump back on and watch the end of it.
1:24 With that, it's my pleasure, as I said, to wa welcome Dean Felchshire and Joanna Lillian Tal. So, today we're going to be talking about the future of translational research. And what that means is where we're going to begin. And I can't think of two better speakers to be with us on this. So, Dr. Dr. Dean Felchshire is an MD and PhD, is a professor of medicine oncology at Stanford University School of Medicine, and he's the director of the translational research and applied medicine program or TRAM, which he's led since 2011. His own laboratory investigates how anka genes initiate and sustain cancer. And he has pioneered model systems showing that inactivating a single Anka gene such as Mick can be sufficient to reverse tumor growth, a concept known as Anka gene addiction. So he's going to be talking a little bit about his own experience both as an educator who's someone who's trying to lead researchers through and students and and clinicians through this process of translational research and his own practice.
2:20 Joanna Lillenal a PhD is an ex is the executive director of Stanford's masters in translational research and applied medicine. She's the director of the translational application service center and the associate director of the translational research in applied medicine program. And since 2011, she has worked alongside Dr. Dean Felchshire mentoring researchers as they move scientific findings from the lab into clinical application including biomarker research for early cancer detection. So welcome welcome Dean Felchshire and Joanna Lill Lillian. It's so great to have you here. I want to start with just a very high level question. Dr. Felure, can you tell us what is translational research? Let's just start at a very high level.
3:04 I'm delighted to answer that question. So at the very highest level, translational research is what we describe when you take an idea discovered in the laboratory and you make it relevant and applicable to something in the real world like a treatment, a therapeutic or a diagnostic. And the and the process of making that actual scientific basic science observation to something real and tangible and useful requires translation and thus the way we describe it as process of translational research.
3:49 >> Can you So following up on that and and this is directed at either of you. What are the challenges? So, we're moving it from from kind of the research bench all the way into the clinic to to an actual therapy that's being used. What are typically some of the challenges or stages that you have to go through and moving a drug or therapy from that researcher's b bench to the patient's bedside? >> Well, I'd like to start answering the question, but like everything we've done about tram, it's been a team effort with Dr. Lillian Tal. We've been doing this together now for 16 years. were scientific siblings basically in this and I would say that I the part I brought to this was I was trained as a doctor and medical doctor and a scientist and I found that it was very difficult sometimes for the two different groups of individuals to talk together in tackling a problem. So scientists in the laboratory sometimes found it hard to know what really were the clinical things that were needed and didn't even know if some science they discovered was useful. And clinicians faced with the challenge of treating and taking care of people sometimes didn't know well how to go about actually doing any science or taking science or even knowing what science was available. So I'd say the first challenge is just getting the different kinds and groups of people who are involved that are required to make something like translational research work together. And a big part of actualizing this is what I then recruited Joanna Lillian Dr. Land to work together with me and and she's I know has lots of thoughts and and examples of how we've thought about together as a team to overcome some of the barriers. Join Dr. Lilian.
5:45 >> Yeah. very well said. So to me one of the biggest challenges is that scientists and I was trained as a scientist myself there often extraordinarily well trained in their own discipline. but drug development really requires more than science. It requires many different disciplines to come together. So you need the science but you also need to understand the clinical need the manufacturing the IP the commercialization and most importantly each of needs to enter Congress. I kind of rephrased what Dean said but more specifically I just wanted to emphasize that a great discovery can fail because some of those questions weren't asked early enough.
6:39 >> >> That's that's wonderful. So coming back again at at a high level here, we've got kind of if I were to break it out, it seems like there are three core stages and I'm sure there's a lot more nuance to that. There's the research that's happening by the scientists in the lab, right? Coming up with novel therapies, novel drugs, novel treatments. And then there's this middle stage which is partly the regulatory stage which is moving these these therapies through the clinical trial through clinical trials for approval and then there's that final stage where you had said you know this is bringing it to the clinics themselves this is helping commercialize get that that that drug or therapy out into the market. So today we're we're talking about the the future of this translational research. So where Dr.
7:25 Lilian have you seen as you've worked on this over the past It's 15 years as part of Tram and and even before that in your own work where have you seen the biggest changes in these three stages and what are the kinds of changes that you've seen? >> Yeah. So it's very interesting that you describe those those sequentially because to me the biggest change is that the boundaries between these stages are disappearing. We used to think more sequentially about discovery than development than commercialization. But what really strikes me as a biggest change I have seen is that you really need to be thinking about those downstream questions much earlier. For instance, the AI and computational approaches are changing discovery.
8:17 biomarkers and patient selection are becoming more and more important in development as well as the commercial and regulatory considerations really influence what we as scientists do very early on. So people who are entering the people who are listening now who are entering the field need to understand the whole ecosystem even if they ultimately specialize in one or the other part.
8:51 >> Dr. Felcher, what would you add to that? >> Well, I think Joanna explained it outstandingly as as as Joanna always does. what I would add is to give an example of where work that we've done together has enabled such process to occur. for example I work on a gene the manka gene and it's relatively obscure to people who are not cancer people but it turns out it's the cancer gene involved in most of human cancer.
9:22 the reality is that the science about knowing Mick as responsible cancers existed for literally decades. His discovery was part of one a Nobel Prize for Mike Bishop and Harold Varmmas. Mike was one of my former mentors. The reality is that to that right now the idea of taking the idea that this is a fulcrum of cancer that's one of the key nodal points of cancer and translating it's exactly as Joanna described solving the riddle of treating cancer involves not just understanding the science but at the same time having an idea well what is the clinical circumstance where it would make sense and knowing chemistry and some of the tricks that have existed to deal with trying to figure out how to target such a such a a gene in our program. We are even talking to our students. Joan and I were talking this morning about how taking advantage of worldclass chemistry going on at Stanford, taking advantage of insights from our clinicians and taking advantage of science discovered by me and other colleagues at Stanford, we can enable our students to actually tackle the problem. And like Joanna said, being aware of all the steps at the same time. I mean, you beautifully summarized the whole translational arc, but it's hard for you to realize because you understand it so well that when Joe and I first trained, nobody was educated in each step of translation. We were usually trained like Joanna and I both trained at UCLA. We were trained in a very specific very specific scientific domain in a specific part of the arc of translation. Whereas now we don't think about problems that way in translational research. A translational research is aware of all aspects. They are aware of the kinds of tools of this that can address scientific questions. They're aware of issues in terms of how to think about proving clinically something would work and they're aware of what will be required to get approval and to get adoption. All of these things need to be aspects of what you know even as Joanna said if you're an expert in a specific aspect.
11:40 That's wonderful. I'd love to dig. So I mean it sounds like actually one of the major things that has just changed in translational research is just the field of translational research is this greater awareness that you cannot work in these sort of siloed field. You cannot be a scientist just working on on a novel treatment. You also have to have insight into these the the clinical trial phase into what it takes to actually implement that in a hospital or in a clinical setting or how to how to even sell it. You know what what are those aspects? So it sounds like that's a major part of it is just this awareness that sounds obsolete part of Yeah.
12:15 >> I would love >> Exactly. >> Yeah. >> Exactly. And and another aspect of this is exactly why I recruited Joanna many years ago is that Joanna in her role Dr. Lillian facilitates across areas of science because sometimes a solution in cancer will actually lead to a solution in another disease. So there has to be a more general understanding and if you're siloed you could miss something right in front of your face. And many times I've heard Joanna bring together somebody from psychiatry and somebody from who's working in immunology to come up with an idea that can lead to a treatment for a psychiatric disorder that may have been thought of something that was involved in the immune system or inflammation or a cardiologist realizing something they've discovered would be useful in cancer. So it's this ability to think across basic and clinical but it's also the ability like you said holistically across the areas of different areas of science and have having an understanding of what would be a solution most importantly to have enough colleagues you know across the areas that you can get help help at different steps that you may not have the most expertise in.
13:35 So I want to come back to that because I think that it sound from what I understand that's a lot of what the tram is doing here at Stanford and this this collab you know this kind of unique spot that's a a university and well not totally unique there are lots of universities with hospitals or vice versa u but I want to maybe dig in a little bit Dr. Lily Tal if you can talk a little bit more about you had mentioned maybe some recent scientific adv advances that had also changed this process. So you mentioned biomarker research and patient selection and also I think what's probably on everybody's mind is some of this stuff around you know advances in data science. I mean, here we are at at Stanford, right? And and obviously artificial intelligence and and maybe more broadly speaking, data science, this ability to look at a lot of data when coming up with whether that's in novel solutions or perhaps in in trying to understand the clinical outcomes, etc. So, I'd love to hear a little bit more if you have some some more insights to share on what you've seen in those scientific advances and how they've been impacting or influencing these these three stages.
14:40 Yeah, definitely the biggest change we have seen over I would say even the last five years is the AI and computational biology and how it drives the discoveries in probably every discipline of medicine and not to replace medicinal chemistry but there are so many new discoveries that make the medicinal chemistries science more robust and and we see a lot of students coming to this area for instance five even five seven years ago there was maybe one spy project right now half of our cohort is trying to solve the problem using AI and computational biology so that's probably the strongest example But overall just to put it at the higher level I think what we do at Tram and how we address that challenge is that sometimes the most valuable thing we can do is simply connect the right people who otherwise might have might never have found each other. and really seeing those collaborations, you know, bringing in a cardiologist and and a computational biology person who can write a code and who can use AI platforms for diagnosis versus someone in infectious disease. So basically it is you know we can think of mechanisms as being finite but ways to address it are infinite. So collaborations can become very interesting because we're it doesn't really matter which disease area you're trying to solve the problem. it can one disease area thought can affect another disease area and we can all learn from each other.
16:47 >> Dr. Felcher, is there anything you would add to that in terms of some of the the specific science or advances that you're really seeing impact what you're doing in interesting ways? >> Well, only to point out having Joanna summarize it beautifully. I'd only point out that we're incredibly sensitive in the in the center to what are the newest areas and we have made our program really organically evolve with the students and fellows and faculty and and we have now as you realize we're going on 20 years of experience in doing this and and the program is definitely much more than Joanna and I always the intention was exactly to take leverage off of the brilliance at Stanford and the brilliance of the people that we bring into our program.
17:42 So it's all that Joanna described but Joan and I just before getting started were talking about students that were going to join our program and how excited we were how much talent they brought. So it's important to realize that that's a very real part of the educational experience in our program is that we incorporate the students who come, people who ask us questions, people who participate in any way and we are constantly evolving the program just like translational research is evolving.
18:12 So we've added new courses. we're adding course we're we're adding we keep adding other elements. We started mainly with therapeutics. We're adding diagnostics. We're adding we've added aspects that enable people to think about vaccine therapy, immune therapy. U all of these were based on what we appreciated were new aspects of program and we're adding formalized elements for mentorship and training in in AI as as as Joan has brought up. So it's not just the in the big picture we appreciate this but we're also fine-tuning and making the program a dynamic just as the field of biotechnology is very dynamic.
18:53 It's also important that we're in an epicenter of success in biotech and many of our adviserss are successful leaders in some of the most exciting companies. We directly collaborate, interact with these individuals and so we're very aware of the pulse of what it is that is being successful and exciting and we we bring that into our program. We bring that into all of our programs into the education. So the speakers that we invite are not just Stanford faculty of course we have world-class faculty but also people involving the entire as I think I like the way Janna described the whole ecosystem. our whole the whole ecosystem is it involves these individuals.
19:35 >> So I want to then maybe transition. Oh go for it. Yes. Yes. >> I just wanted to add one more aspect of that. So yes we have added the new courses so that students are exposed to those emerging technologies. But one other thing that we have added strategically is we have greatly expanded the experiential component. so students can now pursue individual projects. We call them trip where they work individually in labs of a faculty mentor and but they can also work in team projects where multidisciplinary teams work together on real translational challenges. And that team experience is particularly important because that is exactly how drug development actually happens.
20:30 >> Wonderful. Joanna, I'm going to just mute you for a sec. Oh, there we go. Perfect. Yes. Okay. that's that's really fascinating. And I we're already you're already transitioning kind of talking about and I guess that's part of it's hard to disentangle these things because you created tram or you helped create Tram here at Stanford. Exactly. to address these kinds of problems. So let's again starting at a high level for those of us those who are joining us who maybe are a data scientist or an AI researcher or maybe they're a doctor at at a hospital what you know outside of sort of the the go enrolling in a specific program. what should they be thinking about as they try to think about how to get more involved or say I'm a clinician and I want to be more aware of the science or I'm a data scientist you know maybe I'm a data scientist and I think well why do I need to know why do I need to know I'm just I'm just looking at I'm just crunching data why do I need to know the end stage or what how it will work in a clinical trial so can you maybe back up and sort of pitch it to those specific people what why do they need to think about these bigger things why is it so important for them to be thinking about the bigger picture and kind of the whole ecosystem as opposed to their one slice. Dr.
21:41 Felchshire, maybe I'll hand it off to you. >> Sure. So, so I'll start, but I think we we we've both thought about this deeply. So one very important reason for there to be an interest pretty much everybody who would be in the audience is that there's such a dramatic change in in the acceleration at which we can translate findings because of advances in science and and and a and biioinformatics and the information that we have. I think there's a real desire whether you're a a scientist or an engineer or a CEO or a medical doctor or a basic scientist to not feel that you've gotten behind and that you're not aware of the state-of-the-art across the range of what is translational science. If you're a medical doctor, diagnostics and therapeutic decision-making are changing before your eyes. in our education programs, you get exposed to how is it changing? What are people doing? How are they thinking about health care? How are they thinking about delivery of health care? If you're a basic scientist working in an area that you know has translational potential, it can help you engage in thinking, well, what is it that I'm doing that could have high value and who how would I go about finding who to talk to in the clinical world or the business world to recognize that value? If you are a business person or an an investor, one challenge is having, access in an organized way to the summation to state-of-the-art knowledge. in many cases, I've interacted with people who are already in biotech doing translational science, but it's hard to keep up with the actual science. It's like the language of the science is challenging. So those are some examples for of of reasons why I think that the sort of curriculum and education programs we've built would be of interest to not only people who are earlier in their stage of career and they want to figure out what they want to do but people who have been already engaged in some aspect of the medical establishment and and want to buff up their ability to understand what is the state-of-the-art in the full range of going from idea to commercialization.
24:04 What are the latest thinking of how this happens? What are people doing? What are the most exciting ideas and applications to develop therapeutics, diagnostics, vaccines, immune modulatory agents, bioengineer, medical devices? So, Dr. Lillian, maybe just digging into that a little bit a little bit more. Let's let's go into some of the specific programs that you're doing within tram that help address this help address this. So I know you've talked a lot about your educational programs, but there's much more than just the educational programs. So could you give us the the broader view of this center and how it you have envisioned it again to help address what it sounds like the core issue is and the core change is just facilitating these conversations between practitioners of different different stages in the process of bringing a discovery to to to the clinic.
25:01 >> Absolutely. So one thing I would emphasize is that TRM is not simply an educational pro program. I already refer to this as an ecosystem. It's an ecosystem around translational medicine. So we bring together clinicians, scientists, industry experts, entrepreneurs and of course learners. And then we support projects, create collaborations, connect people with expertise as well as provide education and mentorship. So the common thread is helping promising science move forward and actually improve patient lives. It's not just creating new applied new applied therapeutics, diagnostic.
25:51 the the common theme is actually making a difference in the patient life. So that's basically ties in together. it's not it's not just the classes, it's it is the entire ecosystem. It's it's all the horizontal learning. It is the learning from experts. It is making the people meet each other who are people who are the stakeholders in this big equation >> and and Dr. Felchshire maybe we could then expand in so that and I really like that concept. It's not about I' I've laid out this arc but fundamentally the mission of this is as a lot of things are is actually improving the patient's life, right? I mean that is that is the end goal, right? We want to bring something from the lab to to to people to improve their lives to help cure something to help treat something. So thinking about that can you talk through the the specific educational purpose? So, you have a you have courses, you have a master's degree, I think a one-year master's degree, as well as the individual courses that are part of a graduate certificate that a a you know, again, a data scientist in the area who's not been admitted to Stanford can be approved to take those courses and earn a graduate certificate. So, can you talk through what what are those courses? How have you structured them to address this problem? And and I guess I already have one follow-up question that I'm going to embed in there already is it sounds like there are two aspects to this challenge. One is you need to facilitate and bring people together to constantly be learning and listening to your colleagues. Now that seems like an ongoing process and so an educational program can't they can do it that once but they can't do it you know you unless they're retaking the courses all the time. So I guess my question is my my follow-up question embedded in there is the the courses themselves will convene these practitioners and give you the state-of-the-art of what is happening across all these fields. How do you also equip people therefore to then go out in the field and continue that education?
27:56 What is is it just awareness of those different aspects? Are there certain skills you're imparting that allow you you know allow the data scientists to to talk to doctors and the doctors to talk to data scientists? That was a big loaded question. So let me pass it back to you. >> Well well let me let me answer the two parts of the question big picture and then I'll go into more specific details about the actual structure of the curriculum. So in big picture the curriculum in some sense gives from beginning middle end the arc of how to do translation with lectures that go all the way from well how do you form a scientific question to how do you test that scientific question? How do you do a clinical study to how do you get the capital, make sure that you have a patent and protection of intellectual property and commercialize and get regulatory approval. So there literally is coursework that takes you through the entire sequence. That's the big picture.
28:55 in terms of the second question. So we use the word ecosystem and as Joanna said we often talk about horizontal and vertical learning and ecosystem in terms of creating environment at Stanford but it's bigger than that. we have trained hundreds of people. We have hundreds of faculty have been associated with the program. We have literally dozens of adviserss that are global adviserss at st from Stanford and several dozen adviserss that are from industry. Our network is huge. The students who are part of our programs maintain part of that network and and we actively keep them as part of the whole system. So when people graduate from any of our programs they often come back to us. many of the people are lecturers who are students or our adviserss who once were students or faculty come back and become part of the global adviserss. former students know each other and they help each other build programs, get jobs, serve as adviserss.
30:08 so the program has an aspect of it that is larger than just simply Joanna and I and the leadership or simply the collection of lecturers. like most outstanding programs the intention is to create a network of individuals who will be leaders who will be mutually supportive and feel a common identity. Now the curric involves a series of classes that lead through each step in translation and they're very specific didactics such as chem chemistry or patent law or vaccine development. there's other specific classes and then there also we've we keep expanding the curriculum to include other areas that we realize students have of interest. but they're very deliberate coursework on specific specific areas of medical translation that we think are part of the core fabric of what everybody needs to have some knowledge about in terms of everybody needs to have some knowledge of how to design a clinical study. If regardless of whether or not you do are going to be a clinical researcher, if you're going to do translation, you have to have the concept of what is a clinical study, what are the basics of designing a clinical study. And similarly in specific domains of science, having some understanding, well, how does one find a small molecule and know that it has some activity? How do you make an assay to detect that?
31:44 and then how does one get regulatory approval? What are the steps for getting an IND for the FDA? What is it that is required? What are some of the medical affairs issues that are required of of a company to remain in compliance with with regulation. So there's a lot of granularity but there's also a lot of big picture and the intention is for people to feel comfortable with the full range. But it's very important that the learning does not end with the program. You're part of a world-class university and you're connected with like-minded, very talented individuals who are also part of the program and you become part of that. as Joanna described, we we're creating an ecosystem. The ecosystem includes the students are part of the program.
32:37 >> Yeah. And to add to this, for me, the goal simply isn't just to teach the students in the classroom. it's to give people a framework to understand the field that will continue to change throughout their careers to give them a different perspective and many of our MTRAM graduates as well as TRM scholars go on to either academic positions as faculty or leaders. in biotech and pharma and they continue to collaborate with us and then this so they invite us for site visits to their companies. They hire our more recent graduates. They provide career development to our current students and more recent graduates. So it becomes a sort of large a ecosystem of course but a really large family of leaders or likeminded people who really speak the same language. It's not just the classroom. It's much more than that.
33:58 >> That's wonderful. You know, we had a great question that I think is is worth asking now and it's just this there's is there a tension between I guess basic science and applied science in this case or and and in fact from what I'm hearing from you you're also bringing in people who are doing basic science and finding the applied research you know the applied mechanism. So I guess do you see that as a basic tension? Is do you have concerns about you know kind of too much of a focus or too much knowledge of these different stages maybe crowding out something that's just basic science research that maybe doesn't seem to have any applied aspect now maybe will down the road or or maybe won't. So let me yeah that that's the you know what is that tension or is there a tension there?
34:41 >> I mean that there is a tension which is part of the reason that Joan and I built the program. it's very very time consuming to take care of people clinically. It's very very time consuming to do basic research. It's very very time consuming to try to run a company to develop a product. And there can be a t this practical tension of just not having enough time to navigate but navigate being able to engage and and what Joan and I have done is create an environment that encourages this to happen and people who in a organized way are excited about this. And on the other side, the reality is that there's daily examples of major major breakthroughs that are being made.
35:32 And I don't want to promote any one particular company but many of the companies that are in the news in breakthroughs in translational research are include science that we provide training and and and guidance regarding u it it's it's very common because there are many examples of breakthroughs happening translationally in the in the Bay Area and our goal is not to force people to engage. But what we do is create an environment makes it very easy and reduces the tension. It makes it easier for an individual with a basic science background to network, connect with somebody with a clinical background. It makes it easier for somebody with a clinical background to find a scientist or find somebody with business experience. Another theme that we haven't talked about but we've implied is a big aspect and this was a major aspect that Joanna's champion was to take a team approach that a lot of what we do is encouraging people to work as teams recognizing that that's often the most effective way of being successful is to bring together people who appreciate each other but you're not expected to become an expert in every area. expected to appreciate the value each person brings. Joan and I appreciate your expertise. We don't have the ability to bring our education programs outside of Stanford. You have built a program. We've known you for years. You built a program that enables us to provide access to this knowledge in a way that's understandable that people can consume in a way that's practical. And we are revolutionaries education with you as an expert in our program. We embrace you as an example of translation.
37:27 >> You are facilitating >> part of too. >> So you're unequivocally you are. >> Yeah. No, that's that's fantastic. And again, I do you know I I have a another good follow-up question that's very specific about the program and offering. So, as we're, you know, I've been referring to drugs or or treatments, but someone was asking, does this does this translational research, does it apply to people who are interested in creating healthcare grade software or clinical devices? Does it also apply to them or is that a is that itself a kind of different field?
38:04 So just very quickly I'm going to to answer that and Dean can elaborate but very quickly our intention originally was not to just concentrate on drugs or therapeutics. Our intention is really a very holistic approach to expand the knowledge of translational medicine which includes therapeutics, diagnostics, devices, computational platforms, preventatives and we can appreciate how every year we get new students who are interested in those aspects of those different aspects. of translational medicine and as I mentioned before there are more and more computational computer scientists and people who are who know machine learning and AI who want to build platforms for diagnostics or devices. So definitely not just therapeutics, it does include all other aspects and we discuss all those other aspects in our courses as well.
39:26 >> Anything you would you would add to that one or Dr. Culture? >> I know I think Joanna stated it perfectly. This is something that completely resonated with both of us from the very beginning. >> >> I have one more question I think. and again I want to remind everyone if you have we've gotten some great questions. If you have more questions feel free to just put them in the Q&A box. We're nearing the end of the presentation.
39:52 but I I'd love to hear now so again what do you think what what do you hope that a someone who takes let's say the graduate certificate what do you hope they would walk away from this program have and what do you think they would still be thinking about in five years? Now again I think we have the high level answer which is that they're they're thinking across these different these different aspects of of of science and application but what else would you be hoping maybe it's just partnership in this long-standing you know >> well at Stanford if there's one general highlevel idea it's we really are hoping people will recognize that they'll become leaders in medical translation and whatever aspect of the domain. They'll be team players. We're going to encourage them to work with other people in their leadership capacity. But we want people to use this as a way to launch themselves to become revitalized or motivated in their own arc. And people who have been part of the program have been from students who are right out of college to people who have significant amount of work experience. Most people have some work experience. We prefer people to have some idea. They've engaged in some aspect of translation. So they have an idea that this sort of program makes sense for them. But we want pe we want to build leaders. We want to build teams. And we hope people will be in positions that some people will want to be a dean felure a professor. Some people want to be a join Lilian, a a director of education, a director of educational programs that build education as a as their major focus whether it be in academia like Dr.
41:41 Lillian Tal or through programs in in industry and we we hope people will be involved in journalism education such as as you playing a role in education and we hope people will become pharma leaders. We hope people will become clinical researchers. We hope people will be involved in each step of the process. If they're an attorney, patent attorney, they'll be more capable of helping drive intellectual property. If they're a venture person, they'll have a wiser appreciation of how to make decisions to launch the best companies. If they're a scientist, they'll be able to do their clinical or basic research more vitalized with greater skill and ability. So there's lots of different areas, but overall I hope we create people who say to themselves, I trained at Stanford and I feel now that the world is open more for me to have a bigger success as a leader in medical translation regardless of where specific aspect of the domain or in the specific setting.
42:46 And just to add to this, traditionally we, I mean, traditional education, has to do with going to the classrooms, doing things internally here at Stanford, but we quickly realized that there is yet another group of people, and these are the working scientists, the clinicians, the industry professionals who need the knowledge, but don't necessarily have the t time or ability to complete a full master's degree or PhD degree or you know full residential degree and that's really where the certificate comes in. We really want to change the the translational medicine mindset not only at Stanford because it's already changing but we want to change it anywhere in the world that needs those changes and and that's the beauty of the certificate course or the certificate program.
43:53 >> I appreciate that. I mean there are a lot of levels where you can get engaged and it does sound like that this is broadly applicable to anybody who's in you know broadly speaking the healthcare field whether you're doing basic science research that might have applications down the road whether you're an epidemiologist maybe even who's helping run or not an epidemiologist but someone who's helping run clinical trials to someone who to a doctor or a venture capitalist or you know or even even someone who just works in a hospital right and who's maybe an administrator helping run in the hospitals day-to-day having that that understanding of that that whole pipeline it's very broadly applicable and probably to people beginning and mid to late stage in their career where they can come back and gain this this >> absolutely and you know yeah the VCs for instance I mean how do you make financial decisions about in who to to invest in if you don't understand the science or if you don't understand some of the more mundane regulatory aspects. I think that in order to make better therapeutics, diagnostics, devices, everyone really needs to understand the entire spectrum of knowledge in translational medicine.
45:11 >> Yeah. And and and we should point out that so far people who have been part of our program have gone into all these areas. So people have come started companies, people have gone and become professors, people have gone and become leaders in driving clinical research in emerging major biotech companies in many many different areas. Our entire intention was to bring the brilliance and the amazing range of abilities at Stanford to the world to enable translational research on a bigger scale on a on a on a much more magnitude scale. I mean Joan and I've often mused that that the what we're doing has an ambition, you know, well beyond any kind of individual project or particular clinical discipline. It's exactly as you described it and realize that one of the themes we've had is we're both trained in PH as PhD scientists and one real advantage of the scientific training is there's a mentorship where there are adviserss but you learn from the other people in the lab and in a good lab there are people who are junior brand new students to very seasoned people who are almost at the range of being professors to people with technical ability and you learn from being amongst people with different interests. us different backgrounds.
46:39 It's the circumstance of where somebody asking a question from another discipline exposes us all to understanding when the more businessoriented person asks a scientific question, the scientists realize that we take for granted. We thought we knew the answer, we don't. When the scientist asks a business question that somebody with more business or legal or medical affairs has more insight, they realize what is not understood by the science the scientist. It it really is the synergy and our excitement is often when the students will say they'll have an epiphany. They'll say, "Joanna, we love this program because we've actualized things we didn't even know.
47:22 We didn't even know what we didn't know. And now we know things. We're just so excited that we have a deeper appreciation. That is the intention. We want to make people better than they were before they joined our program and we hope that they will get we hope they'll feed forward and feed backward that they'll appreciate it and then they'll want to help the next group because if we do it collectively together, we can do it much much much better. And what's also important is that Joanna and I when we ask people to participate at Stanford, it's it's very rare that somebody's not willing to participate. More our challenge is is fitting in as many people who want to participate. So sometimes people don't really believe that the really famous faculty at Stanford. Now generally we are able to accommodate and bring on board many of the most famous scientists most famous leaders at Stanford will participate the dean's office the deans often participate in our program fantastic AI scientists chemist biologist cancer biologists cardiologists infectious disease people all across different domains I mean it's just that never been the issue. And also that's true across the school. Joanna will be modest about it, but I'm not modest in Joanna's behalf. Joanna, having done this for years, knows every other program, every other resource at Stanford. over 16 years of doing this and and and as a consequence, people part of our program, we get questions answered, taking advantage of everything available at Stanford. I mean it's it's just truly remarkable often what we see that that our students and people that are mentored by program are able to accomplish because just the amazing ability that we work as a team.
49:23 I want to thank both of you for joining us today and thank everyone who joined us